Michel Labouesse
نویسنده
چکیده
Michel Labouesse grew up near Paris. He studied maths and physics for a degree in engineering, but subsequently embraced a career in biology. He learned genetics during his PhD with Piotr Slonimski in Gif/Yvette, where he analysed how the nuclear genome controls expression of mitochondrial genes in yeast. He then went on to learn developmental biology of the nematode Caenorhabditis elegans as a postdoc with Bob Horvitz at MIT. He is now a group leader at the Institut de Génétique et Biologie Moléculaire et Cellulaire near Strasbourg. His lab focuses on the analysis of epithelial morphogenesis in C. elegans.
منابع مشابه
Cell adhesion: parallels between vertebrate and invertebrate focal adhesions
Recent studies highlight the striking similarity between vertebrate focal adhesion plaques and Caenorhabditis elegans muscle adhesion structures and position LIM domain proteins as central players at focal adhesions.
متن کاملTissue integrity: Hemidesmosomes and resistance to stress
How do animal tissues resist the shearing forces to which they are exposed during locomotion or harsh encounters with the environment? Genetic analysis in Caenorhabditis elegans is furthering our understanding of the nature and function of the attachments that preserve tissue integrity.
متن کاملEpithelium–Mesenchyme: A Balancing Act of RhoGAP and RhoGEF
Transitions between epithelium and mesenchyme, in either direction, contribute repeatedly to animal development. Three striking papers suggest that distinct components with opposite activities, which together form a complex known for its role in cytokinesis, control these opposite transitions.
متن کاملEpithelial junctions and attachments.
A distinctive feature of polarized epithelial cells is their specialized junctions, which contribute to cell integrity and provide platforms to orchestrate cell shape changes. The chapter discusses the composition and assembly of C. elegans cell-cell and cell-extracellular matrix junctions, proteins that anchor the cytoskeleton and mechanisms involved in establishing epithelial polarity. The fo...
متن کاملRac GTPase signaling in mechanotransduction during embryonic morphogenesis
How cells sense and respond to mechanical forces is attracting considerable attention. We recently demonstrated that mechanical tension originating from one tissue strongly influences the differentiation and morphogenesis of another tissue during C. elegans embryogenesis (Nature 471:99-103). Specifically, we found that the repeated contractions of muscle cells stimulate a signaling cascade invo...
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عنوان ژورنال:
- Current Biology
دوره 15 شماره
صفحات -
تاریخ انتشار 2005